When you operate on a patient, you think everyone’s going to do really well because 90 percent actually do, but 10 percent do really poorly. Using various cultures and animal studies, we can figure out if the genetic background affects who’s going to do worse. http://perfectarianajenkins.universitypunjabi.org/2016/09/13/the-key-to-no-hassle-interview-attire-secrets/What we found is, for example, there’s one gene mutation called ” BRAF ” that is present in 70 percent of patients with thyroid cancer. But when we can identify it in the tumor and the blood, patients tend to do a little bit worse. Also, we’ve identified other genetic changes [that have effects too], that if a genetic mutation is combined with a mutation in “BRAF,” then the combination tends a very poor prognosis for the patient. Now, there are actually drugs that will attack just that mutant gene and silence it. That’s one area of research that we’ve almost taken to completion. In five years, we went from studying only mice all the way to actually giving drugs [based on this research] to patients in our clinics. As a surgeon, you might have done this operation 100 times or maybe just two times. Green: How does that make you feel as a surgeonto get some level of completeness rather than trying to treat the same person over and over? Parangi: That was one of the draws of surgery for me. As a physician, I think you feel a little defeatist.
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